Qué lo que

This phrase was coined in the Dominican Republic where it was used as a colloquial greeting.
This same colloquial greeting may have been derived from others that were used in different parts of the world or at least resembles the American greeting “whats up”.

When said in the middle of a chat, it is usually placed as “qlq”, “klk”, and when analyzed its meaning is quite variable because it depends on the context and the mood with which it is used.

If it is said to you in a fraternal sense or by a close friend you are fond of, surely he/she wants to greet you, and at the same time he/she is asking you how are you?

Now if it is said to you by a person with whom you have a manifest grudge, that is to say, with whom you are fighting or you do not get along well, it is best to be careful because it may be that he is provoking you, or he is saying it in a defiant way, which is why the meaning depends on the context and mood in which it is used.

In general, it is used to greet in a positive or negative way, as well as to inquire about the state you are in.